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Anti-Ovarian Antibodies (AOA)

Anti- Ovarian Antibodies (AOA)

Anti-Ovarian Antibodies (OA) is another of the aggressive Th1 autoimmune disorders, and in this case antibodies attack healthy ovarian tissue. This means that there is damage being done to the follicles and eggs in the ovaries, and is linked to a number of fertility problems:

  • premature ovarian failure (POF)[i]
  • lower pregnancy success rates[ii]
  • reduced function of the corpus luteum
  • low progesterone levels in the luteal phase
  • poor response to IVF stimulation[iii]

OA are often found in small amounts in healthy women; in fact around 30% of normal, healthy women have OA in their blood samples, yet they have no problems in having children. However there is a relationship between higher levels of OA and issues with the ovaries, with one study finding that 70% of women with premature ovarian failure (POF) also had high levels of anti-ovarian antibodies in their bloodstream.[iv]

Testing and Treatment

Testing is done following the woman providing blood samples; the results are usually given as either a positive or negative result.

BM (Biomedical (aka Western) Medicine) treatment is with Steroids (Dexamethasone or Prednisolone and Calcium)

MCM (Modern Chinese Medicine) has a limited success rate with women who test positive for OA, at about 40% of 67 cases, using a Th1 suppressive Chinese herbal formula.


[ii] ‘The possible role of anti-ovarian antibodies in repeated in vitro fertilization failures’ Geva E et al. American Journal of Reproductive Immunology 42(5): 292-6. 1999
[iv] ‘Ovarian antibodies detected by immobilized antigen immunoassay in patients with premature ovarian failure’. Luborsky J et al. Journal of Clinical Endocrinology & Metabolism. 70(1):69-75.1990

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